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small molecule library  (Selleck Chemicals)


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    Structured Review

    Selleck Chemicals small molecule library
    Small Molecule Library, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 73 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bioactive+small+molecule+library/Bioactive+Compound+Library-%E2%85%A1/pmc13006433-355-31-35
    Average 94 stars, based on 73 article reviews
    small molecule library - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Concentration Assay:

    Article Title: A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer
    Article Snippet: .. Briefly, each of 2,100 compounds from the BioActive small molecule library (SelleckChem) was stamped in triplicate onto 384-well plates for a final concentration of 1 uM using an Echo Acoustic Dispenser (Labcyte). .. Next, 500–1000 cells per well was distributed using a Well mate (Thermo Fisher).

    Suspension:

    Article Title: Synthetic Lethal Targeting of Cyclin Dependent Kinase-12-Deficient Prostate Cancer with PARP Inhibitors
    Article Snippet: Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors Jonathan Chou, Troy M. Robinson, Emily A. Egusa, Roshan Lodha, Meng Zhang, Michelle Badura, Mane Mikayelyan, Henry M. Delavan, Jason Swinderman, Chris Wilson, Jun Zhu, Rajdeep Das, Minh Nguyen, Andrea Loehr, Tony Golsorkhi, Andrew Simmons, Wassim Abida, Arul M. Chinnaiyan, Michelle R. Arkin, Eric J.. Small, David A. Quigley, Lixing Yang, Minkyu Kim, Alan Ashworth, and Felix Y. Feng

    Incubation:

    Article Title: Synthetic Lethal Targeting of Cyclin Dependent Kinase-12-Deficient Prostate Cancer with PARP Inhibitors
    Article Snippet: Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors Jonathan Chou, Troy M. Robinson, Emily A. Egusa, Roshan Lodha, Meng Zhang, Michelle Badura, Mane Mikayelyan, Henry M. Delavan, Jason Swinderman, Chris Wilson, Jun Zhu, Rajdeep Das, Minh Nguyen, Andrea Loehr, Tony Golsorkhi, Andrew Simmons, Wassim Abida, Arul M. Chinnaiyan, Michelle R. Arkin, Eric J.. Small, David A. Quigley, Lixing Yang, Minkyu Kim, Alan Ashworth, and Felix Y. Feng

    Screening:

    Article Title: Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons
    Article Snippet: .. Screening was performed using the Selleck Bioactive small molecule library at the ICCB-Longwood Screening Facility at Harvard Medical School, Boston, MA. ..

    Article Title: Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons.
    Article Snippet: .. Screening was performed using the Selleck Bioactive small molecule library at the ICCB-Longwood Screening Facility at Harvard Medical School, Boston, MA. ..

    Article Title: Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons
    Article Snippet: .. Compound library Screening was performed using the Selleck Bioactive small molecule library at the ICCB-Longwood Screening Facility at Harvard Medical School, Boston, MA. ..

    other:

    Article Title: A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer
    Article Snippet: Briefly, each of 2,100 compounds from the BioActive 134 small molecule library (SelleckChem) was stamped in triplicate onto 384-well plates for a final 135 concentration of 1 uM using an Echo Acoustic Dispenser (Labcyte).

    Article Title: Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity.
    Article Snippet: Ferroptosis is closely linked with various pathophysiological processes, including aging, neurodegeneration, ischemia-reperfusion injury, viral infection and, notably, cancer progression; however, its post-translational regulatory mechanisms remain incompletely understood.. Here we revealed a crucial role of S-palmitoylation in regulating ferroptosis through glutathione peroxidase 4 (GPX4), a pivotal enzyme that mitigates lipid peroxidation.. We identified that zinc finger DHHC-domain containing protein 8 (zDHHC8), a n S -a cy lt ra ns ferase that is highly expressed in multiple tumors, palmitoylates GPX4 at Cys75.

    Drug discovery:

    Article Title: Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons
    Article Snippet: .. Compound library Screening was performed using the Selleck Bioactive small molecule library at the ICCB-Longwood Screening Facility at Harvard Medical School, Boston, MA. ..



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